The LGBT Health & Development Program

Keep it Up! 2.0
Keep it Up! 1.5
Keep it Up! 1.0


Keep it Up! 2.0

KIU2.0_logo

Keep It Up! 2.0 (KIU! 2.0) is a multisite randomized control trial (RCT) comparing two versions of an online HIV prevention program for young men who have sex with men (YMSM). The intervention is based on the Information-Motivation-Behavior Skills Model for HIV risk behavior change, principals of E-learning, and qualitative research with ethnically diverse YMSM. KIU! 2.0 is being conducted by researchers at Northwestern University in Chicago, Hunter College in New York City, and Emory University in Atlanta with support from community clinic partners in their cities. The KIU! 2.0 study has three specific aims:

1. Integrate the KIU! intervention into a widely-used health technology platform to increase its scalability, adaptability, and potential for broad implementation.

2. Test the efficacy of the KIU! e-Health intervention in a multisite RCT that meets CDC criteria for “best evidence interventions.”

3. Explore if the KIU! intervention has differential efficacy across important subgroups of YMSM.

KIU! 2.0 is currently in the recruitment phase. A total of 750 ethnically diverse YMSM who test HIV negative will be enrolled from clinics such as Vida/SIDA in Chicago, Callen-Lorde, Gay Men of African Descent (GMAD), Gay Men’s Health Crisis (GMHC), and Harlem United in New York, and AID Atlanta and Ric Crawford in Atlanta.

Investigator:  Brian Mustanski, PhD
Co-Investigators:  George J. Greene, PhD; Jeffrey T. Parsons, PhD; Patrick S. Sullivan, PhD/DVM
Funder:  National Institute on Drug Abuse

KIU2.0 partners


Keep it Up! 1.5

KIU!-staysafe

Keep It Up! 1.5 (KIU! 1.5) is a highly interactive, engaging, and culturally-relevant HIV prevention program tailored to ethnically diverse YMSM. The intervention is based on the Information-Motivation-Behavior Skills Model for HIV risk behavior change, principals of E-learning, and qualitative research with ethnically diverse YMSM.

KIU! 1.5 uses an innovative holistic approach that highlights the role of community, family, and positive relationships in remaining healthy. This differs from traditional HIV prevention programs which often simply focus on HIV knowledge, transmission, or prevention. KIU! 1.5 makes extensive use of videos, games, animation, and humor (when appropriate) to help increase engagement and motivate behavior change by addressing peer norms, personal vulnerability, behavioral intentions, and pros/cons of condom use.

Keep It Up! 1.5 is currently being implemented at Center on Halsted as a city-wide, community-level intervention.

Investigator:  Brian Mustanski, PhD
Co-Investigators:  George J. Greene, PhD; Jill Dispenza
Funder:  Chicago Department of Public Health


Keep it Up! 1.0

KIU!-staysafe

Keep It Up! 1.0 (KIU! 1.0) is a pilot study that evaluated the feasibility, acceptability, and preliminary efficacy of an online, interactive, and highly engaging HIV prevention program. The intervention, guided by the Information-Motivation-Behavioral Skills model, was designed to be delivered to diverse YMSM ages 18 – 24. The goal was for them to “keep it up” and stay HIV negative.

The study, now completed, included 102 sexually active YMSM screened and recruited from five LGBT-focused clinics in Chicago. The intervention was compared to an online didactic HIV knowledge condition. Participants in the intervention arm had a 44% lower rate of unprotected anal sex acts at the 12-week follow-up (p<.05) compared to those in the control arm. Participants also rated the intervention very highly with one participant remarking, “This is the future of gay sex education!”

Investigator:  Brian Mustanski, PhD
Co-Investigators:  Robert Garofalo, MD, MPH; Geril Donenberg, PhD; Colleen Monahan, DC, MPH
Funder:  National Institute of Mental Health


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